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KMID : 1001020210190040197
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Journal of Urologic Oncology
2021 Volume.19 No. 4 p.197 ~ p.222
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Patient-Specific Tumor Microenvironment Models
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Lee Jung-Woo
Kim Ji-A
Shin Young-Jae
Chi Byung-Hoon
Kim Jung-Hoon
Choi Se-Young
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Abstract
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The heterogeneity of cancer makes it difficult to predict the prognosis of treatment. There is still a lack of preclinical model systems that reflect the clinical characteristics of patients who have heterogenetic tumors. Advances in 3-dimentional (3D) cell culture are leading to discoveries that occur in the development and progression of cancer that has not been known. There are many models including patient-derived xenograft, patient-derived organoid and spheroid, patient-derived explant, scaffold-based model, and system-based model. Each 3D model has its strengths and limitations. One model cannot answer every question, so it seems most reason-able to approach multiple models when studying cancer heterogeneity. Hopefully, 3D tumor modeling will make tremendous progress on this path by fusion of innovative biomaterials and advanced modeling techniques that can partially mimic the heterogeneous environment of real tumors.
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KEYWORD
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3D tumor model, Patient-derived explant, Tissue engineering, Microfluidics
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